منابع مشابه
DITOP: drug-induced toxicity related protein database
MOTIVATION Drug-induced toxicity related proteins (DITRPs) are proteins that mediate adverse drug reactions (ADRs) or toxicities through their binding to drugs or reactive metabolites. Collection of these proteins facilitates better understanding of the molecular mechanisms of drug-induced toxicity and the rational drug discovery. Drug-induced toxicity related protein database (DITOP) is such a...
متن کاملGauging reactive metabolites in drug-induced toxicity.
Over the past decades, it has become abundantly clear that enzymes evolved to detoxify and eliminate foreign chemicals from the body, occasionally generate highly reactive metabolites which have toxicological implications. To decrease the probability of late clinical failure or market withdrawal, there has been an increased prioritization on understanding key metabolic processes that might caus...
متن کاملDrug-Induced Oxidative Stress and Toxicity
Reactive oxygen species (ROS) are a byproduct of normal metabolism and have roles in cell signaling and homeostasis. Species include oxygen radicals and reactive nonradicals. Mechanisms exist that regulate cellular levels of ROS, as their reactive nature may otherwise cause damage to key cellular components including DNA, protein, and lipid. When the cellular antioxidant capacity is exceeded, o...
متن کاملDrug Induced Liver Toxicity: a Survey
Liver toxicity refers to damage done to the liver by medications and chemicals. The liver is an essential organ to the human body. Located on the right side of the body behind the ribs, the liver stores nutrients and produces proteins important to remain healthy. One of the main functions of the liver is to remove toxic substances from the bloodstream. This process may be interrupted if toxins ...
متن کاملEndocrine therapy toxicity: management options.
Treatment with adjuvant endocrine therapy, including tamoxifen and the aromatase inhibitors, has resulted in notable improvements in disease-free and overall survival for patients with hormone receptor-positive breast cancer. Despite their proven benefit, however, adherence to and persistence with the medications is poor in part because of bothersome side effects that can negatively affect qual...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 2008
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.132.297